Donor oocyte bank

 

Briefly about egg donation

 

Egg donor bank is a laboratory where in special conditions healthy oocytes are stored. These thoroughly checked oocytes are taken from female donors. To become a healthy biomaterial, egg donors must meet special requirements most important of which are health condition and young age. These conditions provide  the high quality of the egg: the oocytes are formed during intrauterine development then they are affected by the lifestyle of the women. As a result the younger the donor is, the higher are the health and the vitality of his eggs.

Who needs egg donor?

The Efficiency of IVF hangs mainly on quality of the donor egg. Formed during the period of fetus formation they are consumed throughout menstrual cycle, till the entire supply is wasted and ovaries stop functioning. Age of the donor is the main factor of vitality and quality of the egg. Younger donors not only have better quality of eggs but also low frequency of eggs with chromosomal abnormalities. For instance, most cases of Down syndrome occur in women who became pregnant after the age of 38 years. Decrease of fertility is a natural process. Today there is no method to rejuvenate the ovaries. This is why the efficiency of infertility treatment in women after the age of 35 years is extremely low. The maximum results in this case are achieved with donor oocytes. Transplantation of donor eggs is performed in case of different reproductive problems:

1. decreased ovarian reserve
2. premature ovarian failure
3. low quality of oocytes
4. chromosomal translocations and genetic diseases

First positive result of egg transplantation was received in 1984. Since then only in USA 50 thousand babies were born by this method, while donor eggs were used only in 10% of the cases.

Phases of ‘’Egg donor’’ Programare the followings:

1. synchronization of the menstrual cycles of donor and recipient by using oral contraceptives or agonists of GNRHR
2. stimulation of ovulation in donor with gonadotropins
3. introduction of ovulatory dose of chorionic gonadotropin to donor
4. preparation of recipient endometrium with progesterone or estradiol
5. puncture of the ovaries of the donor, fertilization of the oocytes with sperm, transportation of the embryo into the recipient uterus.

 Egg donors go through standard IVF cycle. Recipient takes progesterone or estradiol to prepare the endometrium of the uterus for  implantation. The donor ovarian stimulation is necessary for receiving several oocytes at the same time. Then the oocytes are extracted  by vaginal puncture method and fertilized. Then during 3-5 days embryo is cultivated in the laboratory and implanted into the recipient’s uterus.

Indications for IVF with donor oocytes:

1. lack of oocytes conditioned with the natural menopause, the syndrome of premature ovary emaciation, the state after the removal of ovaries, radio- or chemotherapy, as well as anomalies of the development.
2. functional inferiority of female ovaries, genetic abnormalities, which can be transferred to babies.
3. inefficiency of previous IVF and embryo transfer cycles with the insufficient ovary response to the stimulation of ovulation, embryos of a low quality which doesn’t result in pregnancy.

Contraindications:

1. somatic and psychological diseases which has contraindications for pregnancy;
2. innate development abnormality or acquired deformations of the uterine cavity, which makes it impossible to implant embryos;
3. ovary tumors;
4. hyper-plastic processes in the endometrium,
5. benign uterine tumors requiring operative treatment
6. severe inflammatory diseases of any localization,
7. malignant neoplasms in any localization, including anamnesis.

Availability of the severe male infertility factor doesn’t exclude the use of donor oocytes. Testicular biopsy and intracytoplasmic sperm injection (ICSI) are the two modern methods of the male infertility treatment and can be applied together with donor oocytes. Previously married couples with serious pathologies of oocytes or sperm had only two options: adoption or childlessness. Today the oocyte donorship, TESA and ICSI provide the third option – opportunity for the married couple to jointly experience the pregnancy and the birth of a child. Oocyte donors face certain risk of complications and difficulties conditioned with the necessity to combine their job with donorship cycle and therefore they receive appropriate material compensation for their participation in the donor’s program. The use of donor’s oocytes is a quite expensive treatment method but the efficiency is high as well. The pregnancy rate of IVF with donor eggs is 60-65%. Today medicine has succeeded in egg vitrification (quick freezing). These method will allow to frozen and store donor eggs, which in first place will simplify their use and allow to pass the half year quarantine for follow up of syphilis, AIDS and Hepatitis.

 

Vitromed Reproductive HealthCenter has own donor base, which will meet requirements of the married couples. For consultation, information about the procedure cost, admission registration call

  +(374) 10 75-00-85